目的 研究开环聚合合成聚(乳酸-乙醇酸)(PLGA)的工艺。方法 采用正交实验优选常压合成聚(乳酸-乙醇酸)的工艺条件, 并进行3批重复性验证。结果 最佳工艺条件确定为:催化剂辛酸亚锡和引发剂十二醇的用量分别为0.03%和0.02%, 反应温度160 ℃, 搅拌速率300 r·min-1, 反应10 h。通过筛选两种单体的投料比, 确定合成聚(乳酸-乙醇酸)5050的乙交酯和丙交酯的比例为45∶55。结论 筛选出的工艺能常压合成聚(乳酸-乙醇酸)5050, 产品重均相对分子质量达到52 000, 分布系数为1.5～1.7, 工艺稳定, 质量可控。
Abstract
OBJECTIVE To study the synthesis technique of poly(lactic-co-glycolic acid)(PLGA) via ring-opening polymerization. METHODS Orthogonal experiments were carried out to optimize the synthesis conditions of PLGA under atmospheric condition. Three batches of repeated experiments were conducted to verify the technological conditions. RESULTS The target product could be synthesized by using 0.03%stannous octoate and 0.02%lauryl alcohol reacted at 160 ℃ for 10 h at a stir speed of 300 r·min-1. The ratio of glycolide and lactide was determined to be 45∶55 to ensure the formation of PLGA5050. CONCLUSION The screened out synthesis technique can obtain PLGA5050 with Mw of 52000 and coefficient of distribution between 1.5-1.7 at atmospheric pressure, and its quality is controllable.
关键词
聚(乳酸-乙醇酸) /
正交实验 /
开环聚合 /
缓控释
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Key words
poly(lactic-co-glycolic acid)(PLGA) /
orthogonal experiment /
ring-opening polymerization /
controlled release
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中图分类号：
R944
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参考文献
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